Found 121 of ic50 for PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT
having polymerids = 50002782 and
complexids = 183,184,185,50004013,50004014
having polymerids = 50002782 and
complexids = 183,184,185,50004013,50004014
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals
Curated by ChEMBL
Cubist Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against human phenylalanyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 2.20nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 2.70nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals
Curated by ChEMBL
Cubist Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals
Curated by ChEMBL
Cubist Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureusMore data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals
Curated by ChEMBL
Cubist Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 60nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals
Curated by ChEMBL
Cubist Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureusMore data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 70nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 80nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 100nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston
Astrazeneca R&D Boston
Affinity DataIC50: 100nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMpH: 7.9 T: 2°CAssay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMpH: 2.0Assay Description:The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co...More data for this Ligand-Target Pair